Publications

2026

Socioeconomic Status is Associated with Reward Processing, Interleukin 1β, Striatal Connectivity, and Antidepressant Outcomes in Individuals with Major Depressive Disorder: A CAN-BIND-1 Report
Jani, S., Hassel, S., Foster, J. A., Turecki, G., Bock, N., Churchill, N., Mueller, D. J., Lam, R. W., Taylor, V. H., Milev, R., Soares, C., Rotzinger, S., Rizvi, S. J., Kennedy, S. H., Frey, B. N., & Dunlop, K. (2026). Socioeconomic status is associated with reward processing, interleukin 1β, striatal connectivity, and antidepressant outcomes in individuals with major depressive disorder: A CAN-BIND-1 report. Biological Psychiatry Global Open Science, 6(2), 100649. https://doi.org/10.1016/j.bpsgos.2025.100649

Research Summary: Could Socioeconomic Status Explain Differences in Brain Function and Treatment Outcomes?

The Association Between Body Mass Index and Treatment Outcomes in Major Depressive Disorder: A CAN-BIND-1 Study
Kim, H. K., Jones, B. D. M., Hahn, M. K., Agarwal, S. M., Farzan, F., Frey, B. N., Kennedy, S. H., Foster, J. A., Lam, R. W., Milev, R., Müller, D. J., Parikh, S. V., Soares, C. N., Taylor, V. H., Turecki, G., Uher, R., & Kloiber, S. (2026). The association between body mass index and treatment outcomes in major depressive disorder: A CAN-BIND-1 study. Journal of Psychiatric Research, 198, 252–256. https://doi.org/10.1016/j.jpsychires.2026.03.036

Lam Employment Absence and Productivity Scale (Leaps): Analysis of the Minimal Clinically Important Difference (MCID) in Patients with Major Depressive Disorder Using Data from the CAN-BIND-1 Study
Sachdeva, S., Li, V. W., Chakrabarty, T., Frey, B. N., Hassel, S., Ho, K., Kennedy, S. H., Milev, R., Müller, D. J., Parikh, S. V., Rotzinger, S., Soares, C. N., Taylor, V. H., Uher, R., & Lam, R. W. (2026). Lam Employment Absence and Productivity Scale (Leaps): Analysis of the minimal clinically important difference (MCID) in patients with major depressive disorder using data from the CAN-BIND-1 study. Journal of Affective Disorders, 403, 121451. https://doi.org/10.1016/j.jad.2026.121451

Research Summary: Can Measuring Work Functioning Help Identify Meaningful Recovery in Depression?

Modulation of Brain Temporal Complexity During Treatment for Depression: A CAN-BIND-1 Study Report
Stengel, C., Schwartzmann, B., Chatterjee, R., Atluri, S., Vaghei, Y., Arnott, S. R., Blier, P., Dhami, P., Foster, J. A., Frey, B. N., Lam, R. W., Milev, R., Müller, D. J., Parikh, S. V., Soares, C. N., Uher, R., Turecki, G., Rotzinger, S., Kennedy, S. H., & Farzan, F. (2026). Modulation of Brain Temporal Complexity During Treatment for Depression: A CAN-BIND-1 Study Report. The Canadian Journal of Psychiatry, 71(3), 185–198. https://doi.org/10.1177/07067437251408188

One-Year Actigraphy Study of Sleep and Rest-Activity Rhythms as Markers of Relapse in Depression
Tonon, A. C., Nexha, A., Cunningham, J. E. A., d’Eon, J., Chakrabarty, T., Farzan, F., Foster, J. A., Harkness, K. L., Hassel, S., Ho, K., Lam, R. W., Milev, R., Minuzzi, L., Müller, D. J., Nunes, A., Parikh, S. V., Quilty, L. C., Rotzinger, S., Soares, C. N., … Frey, B. N. (2026). One-year actigraphy study of sleep and rest-activity rhythms as markers of relapse in depression. JAMA Psychiatry, e254453. https://doi.org/10.1001/jamapsychiatry.2025.4453

Research Summary: Can Sleep and Activity Patterns Help Predict Relapse in Depression?

Which Aspects of Anhedonia Predict Response to Pharmacotherapy in Major Depressive Disorder?
Uher, R., Rizvi, S. J., Quilty, L. C., Pavlova, B., Nunes, A., Foster, J. A., Lam, R. W., Milev, R., Müller, D. J., Taylor, V., Soares, C. N., Rotzinger, S., Kennedy, S. H., & Frey, B. N. (2026). Which aspects of anhedonia predict response to pharmacotherapy in major depressive disorder? Psychological Medicine, 56, e2. https://doi.org/10.1017/S0033291725102894

Research Summary: Can Understanding Changes in Pleasure and Motivation Help Us Personalize Depression Care?

Neurophysiological Correlates of Neuroanatomical Dimensions in Major Depressive Disorder: Electroencephalographic Markers of Brain Function and Treatment Outcome
Xiao, W., Woodham, R. D., Antoniades, M., Srinivasan, D., Fan, Y., Erus, G., Garcia, J. A., Arnott, S. R., Chen, T., Choi, K. S., Chin Fatt, C. R., Frey, B. N., Farzan, F., Frøkjær, V. G., Ganz, M., Godlewska, B. R., Hassel, S., Ho, K., McIntosh, A. M., … Fu, C. H. Y. (2026). Neurophysiological correlates of neuroanatomical dimensions in major depressive disorder: Electroencephalographic markers of brain function and treatment outcome. Biological Psychiatry Global Open Science, 6(5), 100750. https://doi.org/10.1016/j.bpsgos.2026.100750

2025

Predicting Relapse of Depressive Episodes During Maintenance Treatment: The Canadian Biomarker Integration Network in Depression (CAN-BIND) Wellness Monitoring in Major Depressive Disorder Study
Lam, R. W., Rnic, K., Nunez, J.-J., Ho, K., LeMoult, J., Nunes, A., Chakrabarty, T., Foster, J. A., Frey, B. N., Harkness, K. L., Hassel, S., Kennedy, S. H., Li, Q. S., Milev, R. V., Quilty, L. C., Rotzinger, S., Soares, C. N., Taylor, V. H., Turecki, G., & Uher, R. (2025). Predicting Relapse of Depressive Episodes During Maintenance Treatment: The Canadian Biomarker Integration Network in Depression (CAN-BIND) Wellness Monitoring in Major Depressive Disorder Study. The Canadian Journal of Psychiatry, 70(7), 565–573. https://doi.org/10.1177/07067437251337603

Research Summary: Wellness Under Watch: Using Wearables and Data to Catch Depression Early

Polygenic Risk Score Analysis of Antidepressant Treatment Outcomes: A CAN-BIND-1 Study Report
Magarbeh, L., Elsheikh, S. S. M., Islam, F., Marshe, V. S., Men, X., Tavakoli, E., Kronenbuerger, M., Kloiber, S., Frey, B. N., Milev, R., Soares, C. N., Parikh, S. V., Placenza, F., Hassel, S., Taylor, V. H., Leri, F., Blier, P., Uher, R., Farzan, F., … Müller, D. J. (2025). Polygenic Risk Score Analysis of Antidepressant Treatment Outcomes: A CAN-BIND-1 Study Report. The Canadian Journal of Psychiatry, 70(7), 552–564. https://doi.org/10.1177/07067437251329073

Research Summary: Can Genetic Risk Scores Help Explain How People With Depression Respond to Antidepressants?

Symptom Network Connectivity Indices as Predictors of Relapse in Major Depressive Disorder
Nunes, A., Pavlova, B., Nuñez, J.-J., Quilty, L. C., Foster, J. A., Harkness, K. L., Ho, K., Lam, R. W., Li, Q. S., Milev, R., Rotzinger, S., Soares, C. N., Taylor, V. H., Turecki, G., Kennedy, S. H., Frey, B. N., Rudzicz, F., & Uher, R. (2025). Symptom network connectivity indices as predictors of relapse in major depressive disorder. Psychiatry Research, 350, 116562. https://doi.org/10.1016/j.psychres.2025.116562

Research Summary: Can Interactions Between Depression Symptoms Help Predict Relapse?

Latent Profile Analysis of Childhood Maltreatment and Neural Markers in Depression
Rowe, J., Nogovitsyn, N., Mazurka, R., Squires, S. D., Hassel, S., Poppenk, J., Dunlop, K., Zamyadi, M., Milev, R. V., Foster, J. A., Arnott, S. R., Lam, R. W., Uher, R., Rotzinger, S., Kennedy, S. H., Frey, B. N., & Harkness, K. L. (2025). Latent profile analysis of childhood maltreatment and neural markers in depression. JAMA Network Open, 8(8), e2525147. https://doi.org/10.1001/jamanetworkopen.2025.25147

Research Summary: Could Childhood Experiences and Brain Patterns Predict Depression Outcomes?

Multi-Voxel Pattern Analysis for Characterizing Functional Connectivity and Neurocognitive Function in Major Depression: A CAN-BIND-1 Report
Rueda, A., Demchenko, I., Tassone, V. K., Gholamali Nezhad, F., Peters, V., Churchill, N. W., Frey, B. N., Hassel, S., Lam, R. W., Milev, R. V., Müller, D. J., Schweizer, T. A., Strother, S. C., Taylor, V. H., Kennedy, S. H., Anteraper, S. A., & Bhat, V. (2025). Multi-voxel pattern analysis for characterizing functional connectivity and neurocognitive function in major depression: A CAN-BIND-1 report. NeuroImage: Clinical, 48, 103840. https://doi.org/10.1016/j.nicl.2025.103840

Standardized EEG for Multi-Site Biomarker-Informed Trials: Implementation in the Canadian Biomarker Integration Network in Depression
Schwartzmann, B., Dhami, P., Chatterjee, R., Blier, P., Foster, J. A., Hassel, S., Ho, K., Lam, R. W., Milev, R., Müller, D. J., Parikh, S. V., Placenza, F., Quilty, L. C., Rosenblat, J., Soares, C. N., Taylor, V. H., Turecki, G., Rotzinger, S., Kennedy, S. H., … Farzan, F. (2025). Standardized eeg for multi-site biomarker-informed trials: Implementation in the canadian biomarker integration network in depression. Clinical Neurophysiology, 178, 2110932. https://doi.org/10.1016/j.clinph.2025.2110932

Research Summary: How CAN-BIND Is Using Brain Waves to Unlock Better Depression Treatments

Neuroanatomical Dimensions in Major Depression Linked to Cognition, Adverse Life Events, Self-Harm, Metabolomics and Genetics
Xiao, W., Woodham, R. D., Cui, Y., Wen, J., Antoniades, M., Srinivasan, D., Fan, Y., Erus, G., Garcia, J. A., Arnott, S. R., Chen, T., Choi, K. S., Chin Fatt, C., Frey, B. N., Frokjaer, V. G., Ganz, M., Godlewska, B. R., Hassel, S., Ho, K., … Fu, C. H. Y. (2025). Neuroanatomical dimensions in major depression linked to cognition, adverse life events, self-harm, metabolomics and genetics. Communications Medicine, 5(1), 502. https://doi.org/10.1038/s43856-025-01219-5

Generalizability of Treatment Outcome Prediction Across Antidepressant Treatment Trials in Depression
Zhukovsky, P., Trivedi, M. H., Weissman, M., Parsey, R., Kennedy, S., & Pizzagalli, D. A. (2025). Generalizability of treatment outcome prediction across antidepressant treatment trials in depression. JAMA Network Open, 8(3), e251310. https://doi.org/10.1001/jamanetworkopen.2025.1310

Research Summary: Predicting Antidepressant Response with Brain Scans and Artificial Intelligence

2024

Assessing remission in major depressive disorder using a functional-structural data fusion pipeline: A CAN-BIND-1 study
Ayyash, S., Davis, A. D., Alders, G. L., MacQueen, G., Strother, S. C., Hassel, S., Zamyadi, M., Arnott, S. R., Harris, J. K., Lam, R. W., Milev, R., Müller, D. J., Kennedy, S. H., Rotzinger, S., Frey, B. N., Minuzzi, L., & Hall, G. B. (2024). Assessing remission in major depressive disorder using a functional-structural data fusion pipeline: A CAN-BIND-1 study. IBRO Neuroscience Reports, 16, 135–146. https://doi.org/10.1016/j.ibneur.2023.12.011

Neuroanatomical Dimensions in Medication-Free Individuals with Major Depressive Disorder and Treatment Response to SSRI Antidepressant Medications or Placebo
Fu, C. H. Y., Antoniades, M., Erus, G., Garcia, J. A., Fan, Y., Arnone, D., Arnott, S. R., Chen, T., Choi, K. S., Fatt, C. C., Frey, B. N., Frokjaer, V. G., Ganz, M., Godlewska, B. R., Hassel, S., Ho, K., McIntosh, A. M., Qin, K., Rotzinger, S., … Davatzikos, C. (2024). Neuroanatomical dimensions in medication-free individuals with major depressive disorder and treatment response to SSRI antidepressant medications or placebo. Nature Mental Health, 2(2), 164–176. https://doi.org/10.1038/s44220-023-00187-w

Atypical Brain Aging and Its Association with Working Memory Performance in Major Depressive Disorder
Ho, N. C. W., Bethlehem, R. A. I., Seidlitz, J., Nogovitsyn, N., Metzak, P., Ballester, P. L., Hassel, S., Rotzinger, S., Poppenk, J., Lam, R. W., Taylor, V. H., Milev, R., Adamson, C., Adler, S., Alexander-Bloch, A. F., Anagnostou, E., Anderson, K. M., Areces-Gonzalez, A., Astle, D. E., … Dunlop, K. (2024). Atypical brain aging and its association with working memory performance in major depressive disorder. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 9(8), 786–799. https://doi.org/10.1016/j.bpsc.2024.04.008

Integrative Genetic Variation, DNA Methylation, and Gene Expression Analysis of Escitalopram and Aripiprazole Treatment Outcomes in Depression: A CAN-BIND-1 Study
Islam, F., Lisoway, A., Oh, E. S., Fiori, L. M., Magarbeh, L., Elsheikh, S. S. M., Kim, H. K., Kloiber, S., Kennedy, J. L., Frey, B. N., Milev, R., Soares, C. N., Parikh, S. V., Placenza, F., Hassel, S., Taylor, V. H., Leri, F., Blier, P., Uher, R., … Müller, D. J. (2024). Integrative genetic variation, DNA methylation, and gene expression analysis of escitalopram and aripiprazole treatment outcomes in depression: A CAN-BIND-1 study. Pharmacopsychiatry, 57(05), 232–244. https://doi.org/10.1055/a-2313-9979

Influence of CYP2C19, CYP2D6, and ABCB1 Gene Variants and Serum Levels of Escitalopram and Aripiprazole on Treatment-Emergent Sexual Dysfunction: A Canadian Biomarker Integration Network in Depression 1 (CAN-BIND 1) Study
Islam, F., Magarbeh, L., Elsheikh, S. S. M., Kloiber, S., Espinola, C. W., Bhat, V., Frey, B. N., Milev, R., Soares, C. N., Parikh, S. V., Placenza, F., Hassel, S., Taylor, V. H., Leri, F., Blier, P., Uher, R., Farzan, F., Lam, R. W., Turecki, G., … Müller, D. J. (2024). Influence of CYP2C19, CYP2D6, and ABCB1 gene variants and serum levels of escitalopram and aripiprazole on treatment-emergent sexual dysfunction: A Canadian Biomarker Integration Network in Depression 1 (CAN-BIND 1) study. The Canadian Journal of Psychiatry, 69(3), 183–195. https://doi.org/10.1177/07067437231203433

Relation of hippocampal volume and SGK1 gene expression to treatment remission in major depression is moderated by childhood maltreatment: A CAN-BIND-1 report
Mazurka, R., Cunningham, S., Hassel, S., Foster, J. A., Nogovitsyn, N., Fiori, L. M., Strother, S. C., Arnott, S. R., Frey, B. N., Lam, R. W., MacQueen, G. M., Milev, R. V., Rotzinger, S., Turecki, G., Kennedy, S. H., & Harkness, K. L. (2024). Relation of hippocampal volume and SGK1 gene expression to treatment remission in major depression is moderated by childhood maltreatment: A CAN-BIND-1 report. European Neuropsychopharmacology, 78, 71–80. https://doi.org/10.1016/j.euroneuro.2023.12.003

Endocannabinoid Concentrations in Major Depression: Effects of Childhood Maltreatment and Relation to Hippocampal Volume
Mazurka, R., Harkness, K. L., Hassel, S., Stensson, N., Nogovitsyn, N., Poppenk, J., Foster, J. A., Squires, S. D., Rowe, J., Milev, R. V., Wynne-Edwards, K. E., Turecki, G., Strother, S. C., Arnott, S. R., Lam, R. W., Rotzinger, S., Kennedy, S. H., Frey, B. N., & Mayo, L. M. (2024). Endocannabinoid concentrations in major depression: Effects of childhood maltreatment and relation to hippocampal volume. Translational Psychiatry, 14(1), 431. https://doi.org/10.1038/s41398-024-03151-z

Stressful Life Events and Reward Processing in Adults: Moderation by Depression and Anhedonia
Min, S., Mazurka, R., Pizzagalli, D. A., Whitton, A. E., Milev, R. V., Bagby, R. M., Kennedy, S. H., & Harkness, K. L. (2024). Stressful life events and reward processing in adults: Moderation by depression and anhedonia. Depression and Anxiety, 2024, 1–13. https://doi.org/10.1155/2024/8853631

An Empirical Analysis of Structural Neuroimaging Profiles in a Staging Model of Depression
Nogovitsyn, N., Ballester, P., Lasby, M., Dunlop, K., Ceniti, A. K., Squires, S., Rowe, J., Ho, K., Suh, J., Hassel, S., Souza, R., Casseb, R. F., Harris, J. K., Zamyadi, M., Arnott, S. R., Strother, S. C., Hall, G., Lam, R. W., Poppenk, J., … Frey, B. N. (2024). An empirical analysis of structural neuroimaging profiles in a staging model of depression. Journal of Affective Disorders, 351, 631–640. https://doi.org/10.1016/j.jad.2024.01.246

Depression-Anxiety Coupling Strength as a Predictor of Relapse in Major Depressive Disorder: A CAN-BIND Wellness Monitoring Study Report
Nunes, A., Pavlova, B., Cunningham, J. E. A., Nuñez, J.-J., Quilty, L. C., Foster, J. A., Harkness, K. L., Ho, K., Lam, R. W., Li, Q. S., Milev, R., Rotzinger, S., Soares, C. N., Taylor, V. H., Turecki, G., Kennedy, S. H., Frey, B. N., Rudzicz, F., & Uher, R. (2024). Depression-Anxiety Coupling Strength as a predictor of relapse in major depressive disorder: A CAN-BIND wellness monitoring study report. Journal of Affective Disorders, 361, 189–197. https://doi.org/10.1016/j.jad.2024.06.023

Modulation of Neural Oscillations in Escitalopram Treatment: A Canadian Biomarker Integration Network in Depression Study
Schwartzmann, B., Chatterjee, R., Vaghei, Y., Quilty, L. C., Allen, T. A., Arnott, S. R., Atluri, S., Blier, P., Dhami, P., Foster, J. A., Frey, B. N., Kloiber, S., Lam, R. W., Milev, R., Müller, D. J., Soares, C. N., Stengel, C., Parikh, S. V., Turecki, G., … Farzan, F. (2024). Modulation of neural oscillations in escitalopram treatment: A Canadian Biomarker Integration Network in Depression study. Translational Psychiatry, 14(1), 432. https://doi.org/10.1038/s41398-024-03110-8

Functional Neuroimaging Biomarkers of Anhedonia Response to Escitalopram Plus Adjunct Aripiprazole Treatment for Major Depressivedisorder
Vaccarino, S. R., Wang, S., Rizvi, S. J., Lou, W., Hassel, S., MacQueen, G. M., Ho, K., Frey, B. N., Lam, R. W., Milev, R. V., Rotzinger, S., Ravindran, A. V., Strother, S. C., & Kennedy, S. H. (2024). Functional neuroimaging biomarkers of anhedonia response to escitalopram plus adjunct aripiprazole treatment for major depressive disorder. BJPsych Open, 10(1), e18. https://doi.org/10.1192/bjo.2023.588

Large Individual Differences in Functional Connectivity in the Context of Major Depression and Antidepressant Pharmacotherapy
Van Der Wijk, G., Zamyadi, M., Bray, S., Hassel, S., Arnott, S. R., Frey, B. N., Kennedy, S. H., Davis, A. D., Hall, G. B., Lam, R. W., Milev, R., Müller, D. J., Parikh, S., Soares, C., Macqueen, G. M., Strother, S. C., & Protzner, A. B. (2024). Large individual differences in functional connectivity in the context of major depression and antidepressant pharmacotherapy. Eneuro, 11(6), ENEURO.0286-23.2024. https://doi.org/10.1523/ENEURO.0286-23.2024

2023

Gray Matter Volume Drives the Brain Age Gap in Schizophrenia: A SHAP Study
Ballester, P. L., Suh, J. S., Ho, N. C. W., Liang, L., Hassel, S., Strother, S. C., Arnott, S. R., Minuzzi, L., Sassi, R. B., Lam, R. W., Milev, R., Müller, D. J., Taylor, V. H., Kennedy, S. H., Reilly, J. P., Palaniyappan, L., Dunlop, K., & Frey, B. N. (2023). Gray matter volume drives the brain age gap in schizophrenia: A SHAP study. Schizophrenia, 9(1), 3. https://doi.org/10.1038/s41537-022-00330-z

The Course of Insomnia Symptoms During the Acute Treatment of Major Depressive Disorder: A CAN-BIND-1 Report.
Dama, M., Wu, M., Tassone, V. K., Demchenko, I., Frey, B. N., Milev, R. V., Ravindran, A. V., Parikh, S. V., Rotzinger, S., Lou, W., Lam, R. W., Kennedy, S. H., & Bhat, V. (2023). The course of insomnia symptoms during the acute treatment of major depressive disorder: A CAN-BIND-1 report. Psychiatry Research, 325, 115222. https://doi.org/10.1016/j.psychres.2023.115222

Research Summary: Do insomnia symptoms affect antidepressant treatment in depression?

Response Inhibition and Predicting Response to Pharmacological and Cognitive Behavioral Therapy Treatments for Major Depressive Disorder: A CAN-BIND Study
Dhami, P., Quilty, L. C., Schwartzmann, B., Uher, R., Allen, T. A., Kloiber, S., Lam, R. W., MacQueen, G., Frey, B. N., Milev, R., Müller, D. J., Strother, S. C., Blier, P., Soares, C. N., Parikh, S. V., Turecki, G., Foster, J. A., Rotzinger, S., Kennedy, S. H., & Farzan, F. (2023). Response inhibition and predicting response to pharmacological and cognitive behavioral therapy treatments for major depressive disorder: A Canadian Biomarker Integration Network for Depression study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 8(2), 162–170. https://doi.org/10.1016/j.bpsc.2021.12.012

Research Summary: Can brain activity predict responses to medication and therapy for depression?

AI-Based Dimensional Neuroimaging System for Characterizing Heterogeneity in Brain Structure and Function in Major Depressive Disorder: COORDINATE-MDD Consortium Design and Rationale
Fu, C. H. Y., Erus, G., Fan, Y., Antoniades, M., Arnone, D., Arnott, S. R., Chen, T., Choi, K. S., Fatt, C. C., Frey, B. N., Frokjaer, V. G., Ganz, M., Garcia, J., Godlewska, B. R., Hassel, S., Ho, K., McIntosh, A. M., Qin, K., Rotzinger, S., … Davatzikos, C. (2023). AI-based dimensional neuroimaging system for characterizing heterogeneity in brain structure and function in major depressive disorder: COORDINATE-MDD consortium design and rationale. BMC Psychiatry, 23(1), 59. https://doi.org/10.1186/s12888-022-04509-7

The Differential Relation of Emotional, Physical, and Sexual Abuse Histories to Antidepressant Treatment Remission and Persistence of Anhedonia in Major Depression: A CAN-BIND-1 Report
Harkness, K. L., Chakrabarty, T., Rizvi, S. J., Mazurka, R., Quilty, L., Uher, R., Milev, R. V., Frey, B. N., Parikh, S. V., Foster, J. A., Rotzinger, S., Kennedy, S. H., & Lam, R. W. (2023). The differential relation of emotional, physical, and sexual abuse histories to antidepressant treatment remission and persistence of anhedonia in major depression: A CAN-BIND-1 report. The Canadian Journal of Psychiatry, 68(8), 586–595. https://doi.org/10.1177/07067437231156255

ABCB1 Gene Variants and Antidepressant Treatment Outcomes: A Systematic Review and Meta‐Analysis Including Results from the CAN-BIND 1 Study
Magarbeh, L., Hassel, C., Choi, M., Islam, F., Marshe, V. S., Zai, C. C., Zuberi, R., Gammal, R. S., Men, X., Scherf‐Clavel, M., Enko, D., Frey, B. N., Milev, R., Soares, C. N., Parikh, S. V., Placenza, F., Strother, S. C., Hassel, S., Taylor, V. H., … Müller, D. J. (2023). abcb1 gene variants and antidepressant treatment outcomes: A systematic review and meta‐analysis including results from the CAN-BIND‐1 study. Clinical Pharmacology & Therapeutics, 114(1), 88–117. https://doi.org/10.1002/cpt.2854

Conditioned Anti-Immobility by Ketamine: A Comparison to Escitalopram and Bupropion
Melanson, B., Wolter, M., Leatham, Z., Lapointe, T., Kennedy, S., & Leri, F. (2023). Conditioned anti-immobility by ketamine: A comparison to escitalopram and bupropion. Experimental and Clinical Psychopharmacology, 31(2), 350–361. https://doi.org/10.1037/pha0000573

Predicting Recurrence of Major Depressive Episodes using the Depression Implicit Association Test: A Canadian Biomarker Integration Network in Depression (CAN-BIND) Report
Rnic, K., LeMoult, J., Torres, I. J., Chakrabarty, T., Foster, J., Frey, B. N., Harkness, K. L., Ho, K., Li, Q. S., Milev, R., Quilty, L. C., Rotzinger, S., Soares, C. N., Uher, R., Kennedy, S. H., & Lam, R. W. (2023). Predicting recurrence of major depressive episodes using the Depression Implicit Association Test: A Canadian Biomarker Integration Network in Depression (CAN-BIND) report. Psychiatry Research, 330, 115606. https://doi.org/10.1016/j.psychres.2023.115606

Prediction of Depression Treatment Outcome from Multimodal Data: A CAN-BIND-1 Report
Sajjadian, M., Uher, R., Ho, K., Hassel, S., Milev, R., Frey, B. N., Farzan, F., Blier, P., Foster, J. A., Parikh, S. V., Müller, D. J., Rotzinger, S., Soares, C. N., Turecki, G., Taylor, V. H., Lam, R. W., Strother, S. C., & Kennedy, S. H. (2023). Prediction of depression treatment outcome from multimodal data: A CAN-BIND-1 report. Psychological Medicine, 53(12), 5374–5384. https://doi.org/10.1017/S0033291722002124

Applications of Speech Analysis in Psychiatry
Dikaios, K., Rempel, S., Dumpala, S. H., Oore, S., Kiefte, M., & Uher, R. (2023). Applications of speech analysis in psychiatry. Harvard Review of Psychiatry, 31(1), 1–13. https://doi.org/10.1097/HRP.0000000000000356

2022

Cerebello-Cerebral Functional Connectivity Networks in Major Depressive Disorder: A CAN-BIND-1 Study Report
Anteraper, S. A., Guell, X., Lee, Y. J., Raya, J., Demchenko, I., Churchill, N. W., Frey, B. N., Hassel, S., Lam, R. W., MacQueen, G. M., Milev, R., Schweizer, T. A., Strother, S. C., Whitfield-Gabrieli, S., Kennedy, S. H., Bhat, V., & CAN-BIND Investigator Team. (2022). Cerebello-cerebral functional connectivity networks in major depressive disorder: A CAN-BIND-1 study report. The Cerebellum, 22(1), 26–36. https://doi.org/10.1007/s12311-021-01353-5

Brain Age in Mood and Psychotic Disorders: A Systematic Review and Meta‐Analysis
Ballester, P. L., Romano, M. T., De Azevedo Cardoso, T., Hassel, S., Strother, S. C., Kennedy, S. H., & Frey, B. N. (2022). Brain age in mood and psychotic disorders: A systematic review and meta‐analysis. Acta Psychiatrica Scandinavica, 145(1), 42–55. https://doi.org/10.1111/acps.13371

“One Degree of Separation”: A Mixed-Methods Evaluation of Canadian Mental Health Care User and Provider Experiences With Remote Care During COVID-19
Ceniti, A. K., Abdelmoemin, W. R., Ho, K., Kang, Y., Placenza, F., Laframboise, R., Bhat, V., Foster, J. A., Frey, B. N., Lam, R. W., Milev, R., Rotzinger, S., Soares, C. N., Uher, R., & Kennedy, S. H. (2022). “One degree of separation”: A mixed-methods evaluation of canadian mental health care user and provider experiences with remote care during covid-19. The Canadian Journal of Psychiatry, 67(9), 712–722. https://doi.org/10.1177/07067437211070656

Rhythmicity of Sleep and Clinical Outcomes in Major Depressive Disorder: A CAN-BIND-1 Report
Dama, M., Khoo, Y., Frey, B. N., Milev, R. V., Ravindran, A. V., Parikh, S. V., Rotzinger, S., Lou, W., Lam, R. W., Kennedy, S. H., & Bhat, V. (2022). Rhythmicity of sleep and clinical outcomes in major depressive disorder: A CAN-BIND-1 report. Journal of Affective Disorders Reports, 9, 100370. https://doi.org/10.1016/j.jadr.2022.100370

Biophysical Compartment Models for Single-Shell Diffusion MRI in the Human Brain: A Model Fitting Comparison
Davis, A. D., Hassel, S., Arnott, S. R., Hall, G. B., Harris, J. K., Zamyadi, M., Downar, J., Frey, B. N., Lam, R. W., Kennedy, S. H., & Strother, S. C. (2022). Biophysical compartment models for single-shell diffusion MRI in the human brain: A model fitting comparison. Physics in Medicine & Biology, 67(5), 055009. https://doi.org/10.1088/1361-6560/ac46de

Males and Females Differ in Reported Sexual Functioning with Escitalopram Treatment for Major Depressive Disorder: A CAN-BIND-1 Study Report
Espinola, C. W., Khoo, Y., Parmar, R., Demchenko, I., Frey, B. N., Milev, R. V., Ravindran, A. V., Parikh, S. V., Ho, K., Rotzinger, S., Lou, W., Lam, R. W., Kennedy, S. H., & Bhat, V. (2022). Males and females differ in reported sexual functioning with escitalopram treatment for major depressive disorder: A CAN-BIND-1 study report. Journal of Psychopharmacology, 36(5), 604–613. https://doi.org/10.1177/02698811221095832

Pretreatment Anxious Depression as a Predictor of Side Effect Frequency and Severity in Escitalopram and Aripiprazole Adjunctive Therapy
Espinola, C. W., Khoo, Y., Parmar, R., Demchenko, I., Frey, B. N., Milev, R. V., Ravindran, A. V., Parikh, S. V., Ho, K., Rotzinger, S., Lou, W., Lam, R. W., Kennedy, S. H., Bhat, V., & the CAN‐BIND Investigator Team. (2022). Pretreatment anxious depression as a predictor of side effect frequency and severity in escitalopram and aripiprazole adjunctive therapy. Brain and Behavior, 12(5), e2555. https://doi.org/10.1002/brb3.2555

Predicting Escitalopram Treatment Response from Pre-Treatment and Early Response Resting State fMRI in a Multi-Site sample: A CAN-BIND-1 Report
Harris, J. K., Hassel, S., Davis, A. D., Zamyadi, M., Arnott, S. R., Milev, R., Lam, R. W., Frey, B. N., Hall, G. B., Müller, D. J., Rotzinger, S., Kennedy, S. H., Strother, S. C., MacQueen, G. M., & Greiner, R. (2022). Predicting escitalopram treatment response from pre-treatment and early response resting state fMRI in a multi-site sample: A CAN-BIND-1 report. NeuroImage: Clinical, 35, 103120. https://doi.org/10.1016/j.nicl.2022.103120

Acute and Chronic Stress Predict Anti-Depressant Treatment Outcome and Naturalistic Course of Major Depression: A CAN-BIND Report
Hicks, O., McInerney, S. J., Lam, R. W., Milev, R. V., Frey, B. N., Soares, C. N., Foster, J. A., Rotzinger, S., Kennedy, S. H., & Harkness, K. L. (2022). Acute and chronic stress predict anti-depressant treatment outcome and naturalistic course of major depression: A CAN-BIND report. Journal of Affective Disorders, 313, 8–14. https://doi.org/10.1016/j.jad.2022.06.058

Effects of CYP2C19 and CYP2D6 Gene Variants on Escitalopram and Aripiprazole Treatment Outcome and Serum Levels: Results from the CAN-BIND 1 Study
Islam, F., Marshe, V. S., Magarbeh, L., Frey, B. N., Milev, R. V., Soares, C. N., Parikh, S. V., Placenza, F., Strother, S. C., Hassel, S., Taylor, V. H., Leri, F., Blier, P., Uher, R., Farzan, F., Lam, R. W., Turecki, G., Foster, J. A., Rotzinger, S., … Müller, D. J. (2022). Effects of CYP2C19 and CYP2D6 gene variants on escitalopram and aripiprazole treatment outcome and serum levels: Results from the CAN-BIND 1 study. Translational Psychiatry, 12(1), 366. https://doi.org/10.1038/s41398-022-02124-4

Baseline Anxiety, and Early Anxiety/Depression Improvement in Anxious Depression Predicts Treatment Outcomes with escitalopram: A CAN-BIND-1 Study Report
Khoo, Y., Demchenko, I., Frey, B. N., Milev, R. V., Ravindran, A. V., Parikh, S. V., Ho, K., Rotzinger, S., Lou, W., Lam, R. W., Kennedy, S. H., & Bhat, V. (2022). Baseline anxiety, and early anxiety/depression improvement in anxious depression predicts treatment outcomes with escitalopram: A CAN-BIND-1 study report. Journal of Affective Disorders, 300, 50–58. https://doi.org/10.1016/j.jad.2021.12.027

Childhood Trauma and Amygdala Nuclei Volumes in Youth At Risk for Mental Illness
Nogovitsyn, N., Addington, J., Souza, R., Placsko, T. J., Stowkowy, J., Wang, J., Goldstein, B. I., Bray, S., Lebel, C., Taylor, V. H., Kennedy, S. H., & MacQueen, G. (2022). Childhood trauma and amygdala nuclei volumes in youth at risk for mental illness. Psychological Medicine, 52(6), 1192–1199. https://doi.org/10.1017/S0033291720003177

Cerebello-Limbic Functional Connectivity Patterns in Youth at Clinical High Risk for Psychosis
Nogovitsyn, N., Metzak, P. D., Casseb, R. F., Souza, R., Harris, J. K., Prati, L. M., Zamyadi, M., Bray, S. L., Lebel, C., Hassel, S., Strother, S., Goldstein, B. I., Wang, J., Kennedy, S. H., MacQueen, G. M., & Addington, J. (2022). Cerebello-limbic functional connectivity patterns in youth at clinical high risk for psychosis. Schizophrenia Research, 240, 220–227. https://doi.org/10.1016/j.schres.2021.12.041

Common Data Elements to Facilitate Sharing and Re-use of Participant-Level Data: Assessment of Psychiatric Comorbidity Across Brain Disorders
Vaccarino, A. L., Beaton, D., Black, S. E., Blier, P., Farzan, F., Finger, E., Foster, J. A., Freedman, M., Frey, B. N., Gilbert Evans, S., Ho, K., Javadi, M., Kennedy, S. H., Lam, R. W., Lang, A. E., Lasalandra, B., Latour, S., Masellis, M., Milev, R. V., … Evans, K. R. (2022). Common data elements to facilitate sharing and re-use of participant-level data: Assessment of psychiatric comorbidity across brain disorders. Frontiers in Psychiatry, 13, 816465. https://doi.org/10.3389/fpsyt.2022.816465

2021

Interactions Between Neuroticism and Stressful Life Events Predict Response to Pharmacotherapy for Major Depression: A CAN‐BIND 1 Report
Allen, T. A., Harkness, K. L., Lam, R. W., Milev, R., Frey, B. N., Mueller, D. J., Uher, R., Kennedy, S. H., & Quilty, L. C. (2021). Interactions between neuroticism and stressful life events predict response to pharmacotherapy for major depression: A CAN‐BIND 1 report. Personality and Mental Health, 15(4), 273–282. https://doi.org/10.1002/pmh.1514

Exploring Brain Connectivity Changes in Major Depressive Disorder Using Functional‐Structural Data Fusion: A CAN‐BIND‐1 Study
Ayyash, S., Davis, A. D., Alders, G. L., MacQueen, G., Strother, S. C., Hassel, S., Zamyadi, M., Arnott, S. R., Harris, J. K., Lam, R. W., Milev, R., Müller, D. J., Kennedy, S. H., Rotzinger, S., Frey, B. N., Minuzzi, L., Hall, G. B., & CAN‐BIND Investigator Team. (2021). Exploring brain connectivity changes in major depressive disorder using functional‐structural data fusion: A CAN‐BIND‐1 study. Human Brain Mapping, 42(15), 4940–4957. https://doi.org/10.1002/hbm.25590

Accelerated Brain Aging in Major Depressive Disorder and Antidepressant Treatment Response: A CAN-BIND Report
Ballester, P. L., Suh, J. S., Nogovitsyn, N., Hassel, S., Strother, S. C., Arnott, S. R., Minuzzi, L., Sassi, R. B., Lam, R. W., Milev, R., Müller, D. J., Taylor, V. H., Kennedy, S. H., & Frey, B. N. (2021). Accelerated brain aging in major depressive disorder and antidepressant treatment response: A CAN-BIND report. NeuroImage: Clinical, 32, 102864. https://doi.org/10.1016/j.nicl.2021.102864

Metabolomic Signatures Associated with Depression and Predictors of Antidepressant Response in Humans: A CAN-BIND-1 Report
Caspani, G., Turecki, G., Lam, R. W., Milev, R. V., Frey, B. N., MacQueen, G. M., Müller, D. J., Rotzinger, S., Kennedy, S. H., Foster, J. A., & Swann, J. R. (2021). Metabolomic signatures associated with depression and predictors of antidepressant response in humans: A CAN-BIND-1 report. Communications Biology, 4(1), 903. https://doi.org/10.1038/s42003-021-02421-6

Cortisol Reactivity to Stress Predicts Behavioral Responsivity to Reward Moderation by Sex, Depression, and Anhedonia.
Cunningham, S., Mazurka, R., Wynne-Edwards, K. E., Milev, R. V., Pizzagalli, D. A., Kennedy, S., & Harkness, K. L. (2021). Cortisol reactivity to stress predicts behavioral responsivity to reward moderation by sex, depression, and anhedonia. Journal of Affective Disorders, 293, 1–8. https://doi.org/10.1016/j.jad.2021.05.126

Resting State fMRI Scanner Instabilities Revealed by Longitudinal Phantom Scans in a Multi-Center Study
Kayvanrad, A., Arnott, S. R., Churchill, N., Hassel, S., Chemparathy, A., Dong, F., Zamyadi, M., Gee, T., Bartha, R., Black, S. E., Lawrence-Dewar, J. M., Scott, C. J. M., Symons, S., Davis, A. D., Hall, G. B., Harris, J., Lobaugh, N. J., MacQueen, G., Woo, C., & Strother, S. (2021). Resting state fMRI scanner instabilities revealed by longitudinal phantom scans in a multi-center study. NeuroImage, 237, 118197. https://doi.org/10.1016/j.neuroimage.2021.118197

Magnetic Resonance Imaging Sequence Identification Using a Metadata Learning Approach
Liang, S., Beaton, D., Arnott, S. R., Gee, T., Zamyadi, M., Bartha, R., Symons, S., MacQueen, G. M., Hassel, S., Lerch, J. P., Anagnostou, E., Lam, R. W., Frey, B. N., Milev, R., Müller, D. J., Kennedy, S. H., Scott, C. J. M., & The ONDRI Investigators. (2021). Magnetic resonance imaging sequence identification using a metadata learning approach. Frontiers in Neuroinformatics, 15, 622951. https://doi.org/10.3389/fninf.2021.622951

Impacts on Quality of Life with Escitalopram Monotherapy and Aripiprazole Augmentation in Patients with Major Depressive Disorder: A CAN-BIND Report
Morton, E., Bhat, V., Giacobbe, P., Lou, W., Michalak, E. E., Chakrabarty, T., Frey, B. N., Milev, R. V., Müller, D. J., Parikh, S. V., Rotzinger, S., Kennedy, S. H., Lam, R. W., & on behalf of the CAN-BIND Investigator Team. (2021). Impacts on quality of life with escitalopram monotherapy and aripiprazole augmentation in patients with major depressive disorder: A CAN-BIND report. Pharmacopsychiatry, 54(05), 225–231. https://doi.org/10.1055/a-1385-0263

Predictors of Quality of Life Improvement with Escitalopram and Adjunctive Aripiprazole in Patients with Major Depressive Disorder: A CAN-BIND Study Report
Morton, E., Bhat, V., Giacobbe, P., Lou, W., Michalak, E. E., McInerney, S., Chakrabarty, T., Frey, B. N., Milev, R. V., Müller, D. J., Parikh, S. V., Rotzinger, S., Kennedy, S. H., Lam, R. W., & the CAN-BIND Investigator Team. (2021). Predictors of quality of life improvement with escitalopram and adjunctive aripiprazole in patients with major depressive disorder: A CAN-BIND study report. CNS Drugs, 35(4), 439–450. https://doi.org/10.1007/s40263-021-00803-2

Replication of Machine Learning Methods to Predict Treatment Outcome with Antidepressant Medications in Patients with Major Depressive Disorder from STAR*D and CAN-BIND-1
Nunez, J.-J., Nguyen, T. T., Zhou, Y., Cao, B., Ng, R. T., Chen, J., Frey, B. N., Milev, R., Müller, D. J., Rotzinger, S., Soares, C. N., Uher, R., Kennedy, S. H., & Lam, R. W. (2021). Replication of machine learning methods to predict treatment outcome with antidepressant medications in patients with major depressive disorder from STAR*D and CAN-BIND-1. PLOS ONE, 16(6), e0253023. https://doi.org/10.1371/journal.pone.0253023

Association Between Discrepancy in Objective and Subjective Cognitive Abilities and Treatment Response in Patients with Major Depressive Disorder: A CAN-BIND-1 Study Report
Rnic, K., Jung, Y.-E., Torres, I., Chakrabarty, T., LeMoult, J., Vaccarino, A. L., Morton, E., Bhat, V., Giacobbe, P., McInerney, S., Frey, B. N., Milev, R. V., Müller, D., Ravindran, A. V., Rotzinger, S., Kennedy, S. H., & Lam, R. W. (2021). Association between discrepancy in objective and subjective cognitive abilities and treatment response in patients with major depressive disorder: A CAN-BIND-1 study report. Journal of Affective Disorders, 295, 1095–1101. https://doi.org/10.1016/j.jad.2021.09.002

Neuron-Derived Extracellular Vesicles Enriched from Plasma Show Altered Size and miRNA Cargo as a Function of Antidepressant Drug Response
Saeedi, S., Nagy, C., Ibrahim, P., Théroux, J.-F., Wakid, M., Fiori, L. M., Yang, J., Rotzinger, S., Foster, J. A., Mechawar, N., Kennedy, S. H., & Turecki, G. (2021). Neuron-derived extracellular vesicles enriched from plasma show altered size and miRNA cargo as a function of antidepressant drug response. Molecular Psychiatry, 26(12), 7417–7424. https://doi.org/10.1038/s41380-021-01255-2

Research Summary: Can blood samples help predict how well someone will respond to antidepressant medications?

Machine Learning in the Prediction of Depression Treatment Outcomes: A Systematic Review and Meta-Analysis
Sajjadian, M., Lam, R. W., Milev, R., Rotzinger, S., Frey, B. N., Soares, C. N., Parikh, S. V., Foster, J. A., Turecki, G., Müller, D. J., Strother, S. C., Farzan, F., Kennedy, S. H., & Uher, R. (2021). Machine learning in the prediction of depression treatment outcomes: A systematic review and meta-analysis. Psychological Medicine, 51(16), 2742–2751. https://doi.org/10.1017/S0033291721003871

Hypothalamus Volume and DNA Methylation of Stress Axis Genes in Major Depressive Disorder: A CAN-BIND Study Report
Suh, J. S., Fiori, L. M., Ali, M., Harkness, K. L., Ramonas, M., Minuzzi, L., Hassel, S., Strother, S. C., Zamyadi, M., Arnott, S. R., Farzan, F., Foster, J. A., Lam, R. W., MacQueen, G. M., Milev, R., Müller, D. J., Parikh, S. V., Rotzinger, S., Sassi, R. B., … Frey, B. N. (2021). Hypothalamus volume and DNA methylation of stress axis genes in major depressive disorder: A CAN-BIND study report. Psychoneuroendocrinology, 132, 105348. https://doi.org/10.1016/j.psyneuen.2021.105348

Research Summary: Deciphering the Relationship Between Brain Structure and Epigenetics in Depression

Multisite Comparison of MRI Defacing Software Across Multiple Cohorts
Theyers, A. E., Zamyadi, M., O’Reilly, M., Bartha, R., Symons, S., MacQueen, G. M., Hassel, S., Lerch, J. P., Anagnostou, E., Lam, R. W., Frey, B. N., Milev, R., Müller, D. J., Kennedy, S. H., Scott, C. J. M., Strother, S. C., & Arnott, S. R. (2021). Multisite comparison of MRI defacing software across multiple cohorts. Frontiers in Psychiatry, 12, 617997. https://doi.org/10.3389/fpsyt.2021.617997

Baseline Functional Connectivity in Resting State Networks Associated with Depression and Remission Status After 16 Weeks of Pharmacotherapy: A CAN-BIND Report
van der Wijk, G., Harris, J. K., Hassel, S., Davis, A. D., Zamyadi, M., Arnott, S. R., Milev, R., Lam, R. W., Frey, B. N., Hall, G. B., Müller, D. J., Rotzinger, S., Kennedy, S. H., Strother, S. C., MacQueen, G. M., & Protzner, A. B. (2021). Baseline functional connectivity in resting state networks associated with depression and remission status after 16 weeks of pharmacotherapy: A CAN-BIND report. Cerebral Cortex (New York, NY), 32(6), 1223–1243. https://doi.org/10.1093/cercor/bhab286

Research Summary: Is depression associated with changes in brain connections?

Association Between the Expression of lncRNA BASP-AS1 and Volume of Right Hippocampal Tail Moderated By Episode Duration in Major Depressive Disorder: A CAN-BIND 1 Report
Yrondi, A., Fiori, L. M., Nogovitsyn, N., Hassel, S., Théroux, J. F., Aouabed, Z., Frey, B. N., Lam, R. W., Milev, R., Müller, D. J., Foster, J. A., Soares, C., Rotzinger, S., Strother, S. C., MacQueen, G. M., Arnott, S. R., Davis, A. D., Zamyadi, M., Harris, J., … Turecki, G. (2021). Association between the expression of lncRNA BASP-AS1 and volume of right hippocampal tail moderated by episode duration in major depressive disorder: A CAN-BIND 1 report. Translational Psychiatry, 11(1), 469. https://doi.org/10.1038/s41398-021-01592-4

2020

Escitalopram Ameliorates Differences in Neural Activity Between Healthy Comparison and Major Depressive Disorder Groups On An fMRI Emotional Conflict Task: A CAN-BIND-1 Study
Alders, G. L., Davis, A. D., MacQueen, G., Strother, S. C., Hassel, S., Zamyadi, M., Sharma, G. B., Arnott, S. R., Downar, J., Harris, J. K., Lam, R. W., Milev, R., Müller, D. J., Ravindran, A., Kennedy, S. H., Frey, B. N., Minuzzi, L., & Hall, G. B. (2020). Escitalopram ameliorates differences in neural activity between healthy comparison and major depressive disorder groups on an fMRI Emotional conflict task: A CAN-BIND-1 study. Journal of Affective Disorders, 264, 414–424. https://doi.org/10.1016/j.jad.2019.11.068

GPR56/ADGRG1 is Associated with Response to Antidepressant Treatment
Belzeaux, R., Gorgievski, V., Fiori, L. M., Lopez, J. P., Grenier, J., Lin, R., Nagy, C., Ibrahim, E. C., Gascon, E., Courtet, P., Richard-Devantoy, S., Berlim, M., Chachamovich, E., Théroux, J.-F., Dumas, S., Giros, B., Rotzinger, S., Soares, C. N., Foster, J. A., … Turecki, G. (2020). GPR56/ADGRG1 is associated with response to antidepressant treatment. Nature Communications, 11(1), 1635. https://doi.org/10.1038/s41467-020-15423-5

Childhood Maltreatment and Cognitive Functioning in Patients with Major Depressive Disorder: A CAN-BIND-1 Report
Chakrabarty, T., Harkness, K. L., McInerney, S. J., Quilty, L. C., Milev, R. V., Kennedy, S. H., Frey, B. N., MacQueen, G. M., Müller, D. J., Rotzinger, S., Uher, R., & Lam, R. W. (2020). Childhood maltreatment and cognitive functioning in patients with major depressive disorder: A CAN-BIND-1 report. Psychological Medicine, 50(15), 2536–2547. https://doi.org/10.1017/S003329171900268X

Research Summary: Childhood Maltreatment and Cognitive Functioning in Patients with Major Depression
Q&A with Author: Dr. Trisha Chakrabarty

Reverse Translation of Major Depressive Disorder Symptoms: A Framework for the Behavioural Phenotyping of Putative Biomarkers
Daniels, S., Horman, T., Lapointe, T., Melanson, B., Storace, A., Kennedy, S. H., Frey, B. N., Rizvi, S. J., Hassel, S., Mueller, D. J., Parikh, S. V., Lam, R. W., Blier, P., Farzan, F., Giacobbe, P., Milev, R., Placenza, F., Soares, C. N., Turecki, G., … Leri, F. (2020). Reverse translation of major depressive disorder symptoms: A framework for the behavioural phenotyping of putative biomarkers. Journal of Affective Disorders, 263, 353–366. https://doi.org/10.1016/j.jad.2019.11.108

Clinical, Behavioral, and Neural Measures of Reward Processing Correlate with Escitalopram Response in Depression: A Canadian Biomarker Integration Network in Depression (CAN-BIND-1) Report
Dunlop, K., Rizvi, S. J., Kennedy, S. H., Hassel, S., Strother, S. C., Harris, J. K., Zamyadi, M., Arnott, S. R., Davis, A. D., Mansouri, F., Schulze, L., Ceniti, A. K., Lam, R. W., Milev, R., Rotzinger, S., Foster, J. A., Frey, B. N., Parikh, S. V., Soares, C. N., … Downar, J. (2020). Clinical, behavioral, and neural measures of reward processing correlate with escitalopram response in depression: A Canadian Biomarker Integration Network in Depression (CAN-BIND-1) Report. Neuropsychopharmacology, 45(8), 1390–1397. https://doi.org/10.1038/s41386-020-0688-x

Collaborating with Individuals with Lived Experience to Adapt CANMAT Clinical Depression Guidelines into a Patient Treatment Guide: The CHOICE‐D Co‐Design Process
Fonseka, T. M., Pong, J. T., Kcomt, A., Kennedy, S. H., & Parikh, S. V. (2020). Collaborating with individuals with lived experience to adapt CANMAT clinical depression guidelines into a patient treatment guide: The CHOICE‐D co‐design process. Journal of Evaluation in Clinical Practice, 26(4), 1259–1269. https://doi.org/10.1111/jep.13308

Research Summary: CHOICE-D: Empowering Patients with a Plain-Language Guide to Depression Treatment

Reliability of a Functional Magnetic Resonance Imaging Task of Emotional Conflict in Healthy Participants
Hassel, S., Sharma, G. B., Alders, G. L., Davis, A. D., Arnott, S. R., Frey, B. N., Hall, G. B., Harris, J. K., Lam, R. W., Milev, R., Müller, D. J., Rotzinger, S., Zamyadi, M., Kennedy, S. H., Strother, S. C., & MacQueen, G. M. (2020). Reliability of a functional magnetic resonance imaging task of emotional conflict in healthy participants. Human Brain Mapping, 41(6), 1400–1415. https://doi.org/10.1002/hbm.24883

Dietary n-6/n-3 Ratio Influences Brain Fatty Acid Composition in Adult Rats
Horman, T., Fernandes, M. F., Tache, M. C., Hucik, B., Mutch, D. M., & Leri, F. (2020). Dietary n-6/n-3 ratio influences brain fatty acid composition in adult rats. Nutrients, 12(6), 1847. https://doi.org/10.3390/nu12061847

Validation Study of MicroRNAs Previously Associated with Antidepressant Response in Older Adults Treated for Late-Life Depression with Venlafaxine
Marshe, V. S., Islam, F., Maciukiewicz, M., Fiori, L. M., Yerko, V., Yang, J., Turecki, G., Foster, J. A., Kennedy, S. H., Blumberger, D. M., Karp, J. F., Kennedy, J. L., Mulsant, B. H., Reynolds, C. F., Lenze, E. J., & Müller, D. J. (2020). Validation study of microRNAs previously associated with antidepressant response in older adults treated for late-life depression with venlafaxine. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 100, 109867. https://doi.org/10.1016/j.pnpbp.2020.109867

Suicide-Related Presentations of Homeless Individuals to an Inner-City Emergency Department
McInerney, S. J., Fallahi, A., Edgar, N. E., Ceniti, A. K., Rizvi, S. J., Beder, M., Bergmans, Y., & Kennedy, S. H. (2020). Suicide-related presentations of homeless individuals to an inner-city emergency department. General Hospital Psychiatry, 63, 5–6. https://doi.org/10.1016/j.genhosppsych.2019.05.001

Hippocampal Tail Volume as a Predictive Biomarker of Antidepressant Treatment Outcomes in Patients with Major Depressive Disorder: A CAN-BIND Report
Nogovitsyn, N., Muller, M., Souza, R., Hassel, S., Arnott, S. R., Davis, A. D., Hall, G. B., Harris, J. K., Zamyadi, M., Metzak, P. D., Ismail, Z., Downar, J., Parikh, S. V., Soares, C. N., Addington, J. M., Milev, R., Harkness, K. L., Frey, B. N., Lam, R. W., … MacQueen, G. M. (2020). Hippocampal tail volume as a predictive biomarker of antidepressant treatment outcomes in patients with major depressive disorder: A CAN-BIND report. Neuropsychopharmacology, 45(2), 283–291. https://doi.org/10.1038/s41386-019-0542-1

Research Summary: Hippocampal Tail Volume as a Predictive Biomarker of Antidepressant Treatment
Q&A with Author: Dr. Nikita Nogovitsyn

Aberrant Limbic Brain Structures in Young Individuals at Risk for Mental Illness
Nogovitsyn, N., Souza, R., Muller, M., Srajer, A., Metzak, P. D., Hassel, S., Ismail, Z., Protzner, A., Bray, S. L., Lebel, C., MacIntosh, B. J., Goldstein, B. I., Wang, J., Kennedy, S. H., Addington, J., & MacQueen, G. M. (2020). Aberrant limbic brain structures in young individuals at risk for mental illness. Psychiatry and Clinical Neurosciences, 74(5), 294–302. https://doi.org/10.1111/pcn.12985

A Randomized, Crossover Comparison of Ketamine and Electroconvulsive Therapy for Treatment of Major Depressive Episodes: A Canadian Biomarker Integration Network in Depression (CAN-BIND) Study Protocol
Phillips, J. L., Jaworska, N., Kamler, E., Bhat, V., Blier, J., Foster, J. A., Hassel, S., Ho, K., McMurray, L., Milev, R., Moazamigoudarzi, Z., Placenza, F. M., Richard-Devantoy, S., Rotzinger, S., Turecki, G., Vazquez, G. H., Kennedy, S. H., Blier, P., & on behalf of the CAN-BIND Investigator Team. (2020). A randomized, crossover comparison of ketamine and electroconvulsive therapy for treatment of major depressive episodes: A Canadian Biomarker Integration Network in Depression (CAN-BIND) study protocol. BMC Psychiatry, 20(1), 268. https://doi.org/10.1186/s12888-020-02672-3

White Matter Connectivity in Youth at Risk for Serious Mental Illness: A Longitudinal Analysis
Shakeel, M. K., MacQueen, G., Addington, J., Metzak, P. D., Georgopoulos, G., Bray, S., Goldstein, B. I., MacIntosh, B. J., Wang, J., Kennedy, S. H., & Lebel, C. (2020). White matter connectivity in youth at risk for serious mental illness: A longitudinal analysis. Psychiatry Research: Neuroimaging, 302, 111106. https://doi.org/10.1016/j.pscychresns.2020.111106

An Investigation of Cortical Thickness and Antidepressant Response in Major Depressive Disorder: A CAN-BIND Study Report
Suh, J. S., Minuzzi, L., Raamana, P. R., Davis, A., Hall, G. B., Harris, J., Hassel, S., Zamyadi, M., Arnott, S. R., Alders, G. L., Sassi, R. B., Milev, R., Lam, R. W., MacQueen, G. M., Strother, S. C., Kennedy, S. H., & Frey, B. N. (2020). An investigation of cortical thickness and antidepressant response in major depressive disorder: A CAN-BIND study report. NeuroImage: Clinical, 25, 102178. https://doi.org/10.1016/j.nicl.2020.102178

Symptom Dimension of Interest-Activity Indicates Need for Aripiprazole Augmentation of Escitalopram in Major Depressive Disorder: A CAN-BIND-1 Report
Uher, R., Frey, B. N., Quilty, L. C., Rotzinger, S., Blier, P., Foster, J. A., Müller, D. J., Ravindran, A. V., Soares, C. N., Turecki, G., Parikh, S. V., Milev, R., MacQueen, G., Lam, R. W., Kennedy, S. H., & on behalf of the CAN-BIND Investigator Team. (2020). Symptom dimension of interest-activity indicates need for aripiprazole augmentation of escitalopram in major depressive disorder: A CAN-BIND-1 report. The Journal of Clinical Psychiatry, 81(4). https://doi.org/10.4088/JCP.20m13229

Childhood Maltreatment and the Clinical Characteristics of Major Depressive Disorder in Adolescence and Adulthood
Vallati, M., Cunningham, S., Mazurka, R., Stewart, J. G., Larocque, C., Milev, R. V., Bagby, R. M., Kennedy, S. H., & Harkness, K. L. (2020). Childhood maltreatment and the clinical characteristics of major depressive disorder in adolescence and adulthood. Journal of Abnormal Psychology, 129(5), 469–479. https://doi.org/10.1037/abn0000521

Association Between Side Effects and Blood Microrna Expression Levels and Their Targeted Pathways in Patients with Major Depressive Disorder Treated By a Selective Serotonin Reuptake Inhibitor, Escitalopram: A CAN-BIND-1 Report
Yrondi, A., Fiori, L. M., Frey, B. N., Lam, R. W., MacQueen, G. M., Milev, R., Müller, D. J., Foster, J. A., Kennedy, S. H., & Turecki, G. (2020). Association between side effects and blood microrna expression levels and their targeted pathways in patients with major depressive disorder treated by a selective serotonin reuptake inhibitor, escitalopram: A CAN-BIND-1 report. International Journal of Neuropsychopharmacology, 23(2), 88–95. https://doi.org/10.1093/ijnp/pyz066

Use of Machine Learning for Predicting Escitalopram Treatment Outcome From Electroencephalography Recordings in Adult Patients with Depression
Zhdanov, A., Atluri, S., Wong, W., Vaghei, Y., Daskalakis, Z. J., Blumberger, D. M., Frey, B. N., Giacobbe, P., Lam, R. W., Milev, R., Mueller, D. J., Turecki, G., Parikh, S. V., Rotzinger, S., Soares, C. N., Brenner, C. A., Vila-Rodriguez, F., McAndrews, M. P., Kleffner, K., … Farzan, F. (2020). Use of machine learning for predicting escitalopram treatment outcome from electroencephalography recordings in adult patients with depression. JAMA Network Open, 3(1), e1918377. https://doi.org/10.1001/jamanetworkopen.2019.18377

Research Summary: Can machine learning be used as a tool to predict depression treatment outcomes using brain activity?

2019

Reduced Accuracy Accompanied By Reduced Neural Activity During the Performance of an Emotional Conflict Task By Unmedicated Patients with Major Depression: A CAN-BIND fMRI Study
Alders, G. L., Davis, A. D., MacQueen, G., Strother, S. C., Hassel, S., Zamyadi, M., Sharma, G. B., Arnott, S. R., Downar, J., Harris, J. K., Lam, R. W., Milev, R., Müller, D. J., Ravindran, A., Kennedy, S. H., Frey, B. N., Minuzzi, L., & Hall, G. B. (2019). Reduced accuracy accompanied by reduced neural activity during the performance of an emotional conflict task by unmedicated patients with major depression: A CAN-BIND fMRI study. Journal of Affective Disorders, 257, 765–773. https://doi.org/10.1016/j.jad.2019.07.037

Early Change in Reward and Punishment Sensitivity as a Predictor of Response to Antidepressant Treatment for Major Depressive Disorder: A CAN-BIND-1 Report
Allen, T. A., Lam, R. W., Milev, R., Rizvi, S. J., Frey, B. N., MacQueen, G. M., Müller, D. J., Uher, R., Kennedy, S. H., & Quilty, L. C. (2019). Early change in reward and punishment sensitivity as a predictor of response to antidepressant treatment for major depressive disorder: A CAN-BIND-1 report. Psychological Medicine, 49(10), 1629–1638. https://doi.org/10.1017/S0033291718002441

Predicting Worsening Suicidal Ideation With Clinical Features and Peripheral Expression of Messenger RNA and MicroRNA During Antidepressant Treatment.
Belzeaux, R., Fiori, L. M., Lopez, J. P., Boucekine, M., Boyer, L., Blier, P., Farzan, F., Frey, B. N., Giacobbe, P., Lam, R. W., Leri, F., MacQueen, G. M., Milev, R., Müller, D. J., Parikh, S. V., Rotzinger, S., Soares, C. N., Uher, R., Foster, J. A., … Turecki, G. (2019). Predicting worsening suicidal ideation with clinical features and peripheral expression of messenger rna and microrna during antidepressant treatment. The Journal of Clinical Psychiatry, 80(3). https://doi.org/10.4088/JCP.18m12556

White Matter Indices of Medication Response in Major Depression: A Diffusion Tensor Imaging Study
Davis, A. D., Hassel, S., Arnott, S. R., Harris, J., Lam, R. W., Milev, R., Rotzinger, S., Zamyadi, M., Frey, B. N., Minuzzi, L., Strother, S. C., MacQueen, G. M., Kennedy, S. H., & Hall, G. B. (2019). White matter indices of medication response in major depression: A diffusion tensor imaging study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 4(10), 913–924. https://doi.org/10.1016/j.bpsc.2019.05.016

A Pilot Study Investigating the Effect of Music-Based Intervention on Depression and Anhedonia
Janzen, T. B., Al Shirawi, M. I., Rotzinger, S., Kennedy, S. H., & Bartel, L. (2019). A pilot study investigating the effect of music-based intervention on depression and anhedonia. Frontiers in Psychology, 10, 1038. https://doi.org/10.3389/fpsyg.2019.01038

Integrated Genome-Wide Methylation and Expression Analyses Reveal Functional Predictors of Response to Antidepressants
Ju, C., Fiori, L. M., Belzeaux, R., Theroux, J.-F., Chen, G. G., Aouabed, Z., Blier, P., Farzan, F., Frey, B. N., Giacobbe, P., Lam, R. W., Leri, F., MacQueen, G. M., Milev, R., Müller, D. J., Parikh, S. V., Rotzinger, S., Soares, C. N., Uher, R., … Turecki, G. (2019). Integrated genome-wide methylation and expression analyses reveal functional predictors of response to antidepressants. Translational Psychiatry, 9(1), 254. https://doi.org/10.1038/s41398-019-0589-0

Plasma MicroRNA Expression Levels and Their Targeted Pathways in Patients with Major Depressive Disorder Who Are Responsive to Duloxetine Treatment
Kim, H. K., Tyryshkin, K., Elmi, N., Dharsee, M., Evans, K. R., Good, J., Javadi, M., McCormack, S., Vaccarino, A. L., Zhang, X., Andreazza, A. C., & Feilotter, H. (2019). Plasma microRNA expression levels and their targeted pathways in patients with major depressive disorder who are responsive to duloxetine treatment. Journal of Psychiatric Research, 110, 38–44. https://doi.org/10.1016/j.jpsychires.2018.12.007

The Canadian Biomarker Integration Network in Depression (CAN-BIND): Magnetic Resonance Imaging Protocols
MacQueen, G. M., Hassel, S., Arnott, S. R., Addington, J., Bowie, C. R., Bray, S. L., Davis, A. D., Downar, J., Foster, J. A., Frey, B. N., Goldstein, B. I., Hall, G. B., Harkness, K. L., Harris, J., Lam, R. W., Lebel, C., Milev, R., Müller, D. J., Parikh, S. V., … Kennedy, S. H. (2019). The Canadian Biomarker Integration Network in Depression (CAN-BIND): Magnetic resonance imaging protocols. Journal of Psychiatry and Neuroscience, 44(4), 223–236. https://doi.org/10.1503/jpn.180036

Testing a Deep Convolutional Neural Network for Automated Hippocampus Segmentation in a Longitudinal Sample of Healthy Participants
Nogovitsyn, N., Souza, R., Muller, M., Srajer, A., Hassel, S., Arnott, S. R., Davis, A. D., Hall, G. B., Harris, J. K., Zamyadi, M., Metzak, P. D., Ismail, Z., Bray, S. L., Lebel, C., Addington, J. M., Milev, R., Harkness, K. L., Frey, B. N., Lam, R. W., … MacQueen, G. M. (2019). Testing a deep convolutional neural network for automated hippocampus segmentation in a longitudinal sample of healthy participants. NeuroImage, 197, 589–597. https://doi.org/10.1016/j.neuroimage.2019.05.017

Symptomatic and Functional Outcomes and Early Prediction of Response to Escitalopram Monotherapy and Sequential Adjunctive Aripiprazole Therapy in Patients with Major Depressive Disorder: A CAN-BIND-1 Report
Kennedy, S. H., Lam, R. W., Rotzinger, S., Milev, R. V., Blier, P., Downar, J., Evans, K. R., Farzan, F., Foster, J. A., Frey, B. N., Giacobbe, P., Hall, G. B., Harkness, K. L., Hassel, S., Ismail, Z., Leri, F., McInerney, S., MacQueen, G. M., Minuzzi, L., … on behalf of the CAN-BIND Investigator Team. (2019). Symptomatic and functional outcomes and early prediction of response to escitalopram monotherapy and sequential adjunctive aripiprazole therapy in patients with major depressive disorder: A CAN-BIND-1 report. The Journal of Clinical Psychiatry, 80(2). https://doi.org/10.4088/JCP.18m12202

A Study of Limbic Brain Derived Neurotrophic Factor Gene Expression in Male Sprague-Dawley Rats Trained on a Learned Helplessness Task
Storace, A., Daniels, S., Zhou, Y., Kalisch, B., Parker, L., Rock, E., Limebeer, C., Lapointe, T., & Leri, F. (2019). A study of limbic brain derived neurotrophic factor gene expression in male Sprague-Dawley rats trained on a learned helplessness task. Behavioural Brain Research, 376, 112174. https://doi.org/10.1016/j.bbr.2019.112174

2018

Performance of the Biological Rhythms Interview for Assessment in Neuropsychiatry: An Item Response Theory and Actigraphy Analysis
Allega, O. R., Leng, X., Vaccarino, A., Skelly, M., Lanzini, M., Hidalgo, M. P., Soares, C. N., Kennedy, S. H., & Frey, B. N. (2018). Performance of the biological rhythms interview for assessment in neuropsychiatry: An item response theory and actigraphy analysis. Journal of Affective Disorders, 225, 54–63. https://doi.org/10.1016/j.jad.2017.07.047

Big Five Aspects of Personality Interact to Predict Depression
Allen, T. A., Carey, B. E., McBride, C., Bagby, R. M., DeYoung, C. G., & Quilty, L. C. (2018). Big Five aspects of personality interact to predict depression. Journal of Personality, 86(4), 714–725. https://doi.org/10.1111/jopy.12352

The Comparative Effectiveness of Electroencephalographic Indices in Predicting Response to Escitalopram Therapy in Depression: A Pilot Study
Baskaran, A., Farzan, F., Milev, R., Brenner, C. A., Alturi, S., Pat McAndrews, M., Blier, P., Evans, K., Foster, J. A., Frey, B. N., Giacobbe, P., Lam, R. W., Leri, F., MacQueen, G. M., Müller, D. J., Parikh, S. V., Rotzinger, S., Soares, C. N., Strother, S. C., … Kennedy, S. H. (2018). The comparative effectiveness of electroencephalographic indices in predicting response to escitalopram therapy in depression: A pilot study. Journal of Affective Disorders, 227, 542–549. https://doi.org/10.1016/j.jad.2017.10.028

Neuroimaging Biomarkers as Predictors of Treatment Outcome in Major Depressive Disorder
Fonseka, T. M., MacQueen, G. M., & Kennedy, S. H. (2018). Neuroimaging biomarkers as predictors of treatment outcome in Major Depressive Disorder. Journal of Affective Disorders, 233, 21–35. https://doi.org/10.1016/j.jad.2017.10.049

GWAS-Based Machine Learning Approach to Predict Duloxetine Response in Major Depressive Disorder
Maciukiewicz, M., Marshe, V. S., Hauschild, A.-C., Foster, J. A., Rotzinger, S., Kennedy, J. L., Kennedy, S. H., Müller, D. J., & Geraci, J. (2018). GWAS-based machine learning approach to predict duloxetine response in major depressive disorder. Journal of Psychiatric Research, 99, 62–68. https://doi.org/10.1016/j.jpsychires.2017.12.009

Genome-Wide Association Studies of Placebo and Duloxetine Response in Major Depressive Disorder
Maciukiewicz, M., Marshe, V. S., Tiwari, A. K., Fonseka, T. M., Freeman, N., Kennedy, J. L., Rotzinger, S., Foster, J. A., Kennedy, S. H., & Müller, D. J. (2018). Genome-wide association studies of placebo and duloxetine response in major depressive disorder. The Pharmacogenomics Journal, 18(3), 406–412. https://doi.org/10.1038/tpj.2017.29

Presentation and Neurobiology of Anhedonia in Mood Disorders: Commonalities and Distinctions
Rizvi, S. J., Lambert, C., & Kennedy, S. (2018). Presentation and neurobiology of anhedonia in mood disorders: Commonalities and distinctions. Current Psychiatry Reports, 20(2), 13. https://doi.org/10.1007/s11920-018-0877-z

2017

2016

Zebrafish Models of Major Depressive Disorders
Fonseka, T. M., Wen, X., Foster, J. A., & Kennedy, S. H. (2016). Zebrafish models of major depressive disorders. Journal of Neuroscience Research, 94(1), 3–14. https://doi.org/10.1002/jnr.23639

Discovering Biomarkers for Antidepressant Response: Protocol from the Canadian Biomarker Integration Network in Depression (CAN-BIND) and Clinical Characteristics of the First Patient Cohort
Lam, R. W., Milev, R., Rotzinger, S., Andreazza, A. C., Blier, P., Brenner, C., Daskalakis, Z. J., Dharsee, M., Downar, J., Evans, K. R., Farzan, F., Foster, J. A., Frey, B. N., Geraci, J., Giacobbe, P., Feilotter, H. E., Hall, G. B., Harkness, K. L., Hassel, S., … on behalf of the CAN-BIND Investigator Team. (2016). Discovering biomarkers for antidepressant response: Protocol from the Canadian biomarker integration network in depression (CAN-BIND) and clinical characteristics of the first patient cohort. BMC Psychiatry, 16(1), 105. https://doi.org/10.1186/s12888-016-0785-x

Research Summary: Mid-study report on the CAN-BIND-1 study for personalizing depression treatment

The Depression Inventory Development Workgroup: A Collaborative, Empirically Driven Initiative to Develop a New Assessment Tool for Major Depressive Disorder
Vaccarino, A. L., Evans, K. R., Kalali, A. H., Kennedy, S. H., Engelhardt, N., Frey, B. N., Greist, J. H., Kobak, K. A., Lam, R. W., MacQueen, G., Milev, R., Placenza, F. M., Ravindran, A. V., Sheehan, D. V., Sills, T., & Williams, J. B. W. (2016). The depression inventory development workgroup: A collaborative, empirically driven initiative to develop a new assessment tool for major depressive disorder. Innovations in Clinical Neuroscience, 13(9–10), 20–31. https://pmc.ncbi.nlm.nih.gov/articles/PMC5141593/

2015 and Earlier

The Canadian Biomarker Integration Network in Depression (CAN-BIND): Advances in Response Prediction
Kennedy, S.H., Downar, J., R. Evans, K., Feilotter, H., W. Lam, R., M. MacQueen, G., Milev, R., V. Parikh, S., Rotzinger, S., & Soares, C. (2012). The canadian biomarker integration network in depression (CAN-BIND): Advances in response prediction. Current Pharmaceutical Design, 18(36), 5976–5989. https://doi.org/10.2174/138161212803523635

A Novel Procedure for Evaluating the Reinforcing Properties of Tastants in Laboratory Rats: Operant Intraoral Self-administration
Levy, A., Limebeer, C. L., Ferdinand, J., Shillingford, U., Parker, L. A., & Leri, F. (2014). A novel procedure for evaluating the reinforcing properties of tastants in laboratory rats: Operant intraoral self-administration. Journal of Visualized Experiments, (84), 50956. https://doi.org/10.3791/50956

Fructose: Glucose Ratios—A Study of Sugar Self-Administration and Associated Neural and Physiological Responses in the Rat
Levy, A., Marshall, P., Zhou, Y., Kreek, M., Kent, K., Daniels, S., Shore, A., Downs, T., Fernandes, M., Mutch, D., & Leri, F. (2015). Fructose: glucose ratios—A study of sugar self-administration and associated neural and physiological responses in the rat. Nutrients, 7(5), 3869–3890. https://doi.org/10.3390/nu7053869

Genetic Variation in IL-1β, IL-2, IL-6, TSPO and BDNF and Response to Duloxetine or Placebo Treatment in Major Depressive Disorder
Maciukiewicz, M., Marshe, V. S., Tiwari, A. K., Fonseka, T. M., Freeman, N., Rotzinger, S., Foster, J. A., Kennedy, J. L., Kennedy, S. H., & Müller, D. J. (2015). Genetic variation in il-1β, il-2, il-6, tspo and bdnf and response to duloxetine or placebo treatment in major depressive disorder. Pharmacogenomics, 16(17), 1919–1929. https://doi.org/10.2217/pgs.15.136

Restoration of Serotonin Neuronal Firing Following Long-Term Administration of Bupropion but Not Paroxetine in Olfactory Bulbectomized Rats
Mansari, M. E., Manta, S., Oosterhof, C., El Iskandrani, K. S., Chenu, F., Shim, S., & Blier, P. (2015). Restoration of serotonin neuronal firing following long-term administration of bupropion but not paroxetine in olfactory bulbectomized rats. International Journal of Neuropsychopharmacology, 18(4), pyu050–pyu050. https://doi.org/10.1093/ijnp/pyu050